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KMID : 0372919950160040387
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Journal of Biomedical Engineering Research
1995 Volume.16 No. 4 p.387 ~ p.394
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A New Method for Determining the Absorption Coefficient of Oxy- and Deoxyhemoglobin by use of a Thin-fi im Optical Waveguide Sensor
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Abstract
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A simple method for determining the absorption coefficient of oxyhemoglobin and deoxyhemoglobin in human blood is proposed as an application of the complex propagation constant of a guided wave in a thin-film optical waveguide. A serial multichannel sample chamber is constructed on the waveguide to vary the interaction length between the evanescent field and the sample, and the dependence of the sensor response on the interaction length is investigated for the various concentration of two hemoglobins. The sensor response is linearly proportional to the interaction length and the concentration of two hemoglobins. The attenuation constant due to the evanescent field absorption between the samples is experimentally obtained with the designed sensor, and then the absorption coefficient is determined by the proposed method. The absorption coefficients determined by the proposed method fairly well coincided with those obtained by the conventional transmission measurement.
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